Maximizing Options to Advance Informed Choice for HIV Prevention (MOSAIC) is a five-year (2021-2026) global project funded by the U.S. President’s Emergency Plan for AIDS Relief (PEPFAR) through the U.S. Agency for International Development (USAID) to help adolescent girls and young women and other women* prevent HIV by accelerating introduction and scale-up of new and emerging biomedical prevention products.

MOSAIC works across multiple countries to implement user-centered research and research translation efforts to identify, understand, and remove barriers to new product introduction, access, and use; coordinate and provide technical assistance to global, national, and subnational stakeholders to expedite product launch and scale-up; and strengthen the capacity of a wide range of local partners to perform essential functions that support the introduction of HIV prevention products.

The MOSAIC consortium is led by FHI 360 along with core partners Wits RHI, Pangaea Zimbabwe, LVCT Health, Jhpiego, and AVAC. Local partner leadership and engagement, particularly in sub-Saharan Africa, is intrinsic to the project’s approach to expediting women’s access to new HIV prevention products. The work is also supported by technical partners from Afton Bloom, Avenir Health, Columbia University, Mann Global Health, RTI International, the University of Pittsburgh, and the University of Washington.

The MOSAIC NextGen Squad is a team of paid youth advocates under the age of 30 from Eswatini, Kenya, Lesotho, Nigeria, South Africa, Uganda, Zambia, and Zimbabwe. This dynamic group of young people shape, influence, and participate in MOSAIC project activities through local partners. They ultimately hold MOSAIC accountable as it aligns its plans, actions, monitoring and evaluation, and learning efforts to: be responsive to young people’s needs, preferences, and lived experiences; include the diversity of adolescent girls and young women; and meaningfully engage young people in research and research utilization. To access blog posts co-authored by NextGen Squad members, click here.


All questions, comments, and suggestions related to our blog should be directed to Aubrey Weber (

Featured Image (About Page): MOSAIC’s NextGen Squad representatives enjoy time together in Johannesburg, South Africa, during a project gender and youth workshop (David Penney/MOSAIC).

Featured Image (Contact Page): MOSAIC partners at Pangaea Zimbabwe facilitate an HIV Prevention Ambassador training in Harare, Zimbabwe with local public health clinicians (iTAP Media/MOSAIC)

*MOSAIC end users include cisgender women, transgender women, and nonbinary people and transgender men assigned female at birth; in addition, specific underrepresented groups within these end user populations include very young adolescents, sex workers, pregnant and breastfeeding individuals, those engaged in transactional sex, and individuals who use drugs.